Journal article
Allergen Inhalation Challenge: A Human Model of Asthma Exacerbation
Abstract
Allergen challenge by inhalation is a very useful clinical and research tool for evaluating allergic airway disease. Inhalation of allergen leads to cross-linking of allergen-specific IgE bound to IgE receptors on mast cells and basophils. This is followed by activation of secretory pathways to release preformed and newly generated mediators of bronchoconstriction and vascular permeability. The onset of bronchoconstriction, representing the …
Authors
Gauvreau GM; Evans MY
Journal
Contributions to Microbiology, Vol. 14, , pp. 21–32
Publisher
Karger Publishers
Publication Date
2007
DOI
10.1159/000107052
ISSN
1420-9519