Journal article
Influence of censoring on conclusions of trials for women with metastatic breast cancer
Abstract
Progression-free survival and time-to-progression (PFS/TTP) are used commonly as primary end-points in trials evaluating treatments for metastatic breast cancer (MBC). We reviewed the impact of censoring on interpretation of these end-points. A systematic review identified phase 3 trials in MBC published between 2001 and 2012 that reported hazard ratios (HRs) for PFS/TTP and Kaplan-Meier curves indicating numbers at risk. We calculated HRs for …
Authors
Templeton AJ; Ace O; Amir E; Vera-Badillo F; Ocana A; Pond GR; Tannock IF
Journal
European Journal of Cancer, Vol. 51, No. 6, pp. 721–724
Publisher
Elsevier
Publication Date
April 2015
DOI
10.1016/j.ejca.2014.12.016
ISSN
0959-8049