Journal article
The aqueous stability of bupropion
Abstract
In this study the aqueous stability of bupropion was determined and the pH-degradation profile was obtained. The effects of hydrogen ion, solvent and hydroxide ion concentration are discussed with particular emphasis on the kinetics of degradation of bupropion. Kinetics and degradation of bupropion were determined by HPLC-UV and LC-MS analysis both utilising high pH chromatographic methods. Degradation of bupropion in aqueous solutions follows …
Authors
O’Byrne PM; Williams R; Walsh JJ; Gilmer JF
Journal
Journal of Pharmaceutical and Biomedical Analysis, Vol. 53, No. 3, pp. 376–381
Publisher
Elsevier
Publication Date
11 2010
DOI
10.1016/j.jpba.2010.04.024
ISSN
0731-7085