Journal article
Ethical issues in stopping randomized trials early because of apparent benefit.
Abstract
Stopping randomized trials early because of an apparent benefit is becoming more common. To protect and promote the interests of trial participants, investigators may feel obligated to stop a trial early because of the apparent benefit of a study treatment (compared with placebo or other treatment). There are, however, serious ethical problems with doing so. Truncated trials systematically overestimate treatment effects; in cases where the …
Authors
Mueller PS; Montori VM; Bassler D; Koenig BA; Guyatt GH
Journal
Annals of Internal Medicine, Vol. 146, No. 12, pp. 878–881
Publisher
American College of Physicians
Publication Date
June 19, 2007
DOI
10.7326/0003-4819-146-12-200706190-00009
ISSN
1056-8751