Induction of hypoxia inducible factor 2α (HIF‐2α) in an immortalized adrenomedullary chromaffin cell line requires mitochondrial‐derived reactive oxygen species

Hypoxia‐induced catecholamine release from adrenomedullary chromaffin cells (AMC) plays a critical role in the ability of the neonate to adapt to air‐breathing life, and occurs via a direct non‐neurogenic mechanism. One important set of regulators in such O2‐sensitive cells is the HIF family of transcription factors (e.g. HIF‐1α, HIF‐2α, HIF‐3α) which are stabilized during hypoxia and can regulate a host of genes that are essential for …