Journal article
GABA Mediates Autoreceptor Feedback Inhibition in the Rat Carotid Body Via Presynaptic GABAB Receptors and TASK‐1
Abstract
Background K+ channels exert control over neuronal excitability by regulating resting potential and input resistance. Here, we show that GABAB receptor-mediated activation of a background K+ conductance modulates transmission at rat carotid body chemosensory synapses in vitro. Carotid body chemoreceptor (type I) cells expressed GABAB(1) and GABAB(2) subunits as well as endogenous GABA. The GABAB receptor agonist baclofen activated an …
Authors
Fearon IM; Zhang M; Vollmer C; Nurse CA
Journal
The Journal of Physiology, Vol. 553, No. 1, pp. 83–94
Publisher
Wiley
Publication Date
11 2003
DOI
10.1113/jphysiol.2003.048298
ISSN
0022-3751
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAutoreceptorsBaclofenCalcium ChannelsCarotid BodyCells, CulturedCyclic AMP-Dependent Protein KinasesElectrophysiologyFeedback, PhysiologicalFluorescent Antibody TechniqueGABA AntagonistsGABA-B Receptor AntagonistsMembrane PotentialsNerve Tissue ProteinsPatch-Clamp TechniquesPotassiumPotassium ChannelsPotassium Channels, Tandem Pore DomainRatsRats, WistarReceptors, G-Protein-CoupledReceptors, GABA-BReceptors, PresynapticReverse Transcriptase Polymerase Chain ReactionSynapsesgamma-Aminobutyric Acid