Journal article
Capsaicin reduces PLGA‐induced fibrosis by promoting M2 macrophages and suppressing overall inflammatory Response
Abstract
Capsaicin reduced poly(lactic-co-glycolic) acid (PLGA)-induced fibrosis by promoting IL-10 secretion and suppressing alpha-smooth muscle actin (α-SMA) expression. The lifetime and efficacy of tissue engineering scaffolds are determined by the foreign body response. In this study, we investigated the in vitro and in vivo effects of capsaicin to reduce biomaterial-induced fibrosis. RAW 264.7 cells cultured on PLGA films with capsaicin responded …
Authors
Truong T; Jones KS
Journal
Journal of Biomedical Materials Research Part A, Vol. 106, No. 9, pp. 2424–2432
Publisher
Wiley
Publication Date
September 2018
DOI
10.1002/jbm.a.36436
ISSN
1549-3296
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsArginaseBiomarkersCadherinsCapsaicinCell AdhesionCollagenCytokinesFibrosisGene Expression Regulation, EnzymologicInflammationKineticsMacrophagesMiceMice, Inbred C57BLNitric Oxide Synthase Type IIPeritoneumPolylactic Acid-Polyglycolic Acid CopolymerProstheses and ImplantsRAW 264.7 CellsUp-Regulation