Journal article
Striatal G-proteins: Effects of unilateral 6-hydroxydopamine lesions
Abstract
To investigate the molecular mechanisms of denervation-induced dopamine receptor supersensitivity, levels of striatal G-proteins were examined in 6-hydroxydopamine (6-OHDA)-lesioned rats. Increased levels of the alpha-subunits of Gs and G(olf), as measured by immunoblotting, were observed 8 days postlesion and remained elevated up to day 28 (25-45% over the time course). G(i) levels were significantly increased only on day 8 (20%) and G(o) …
Authors
Marcotte ER; Sullivan RM; Mishra RK
Journal
Neuroscience Letters, Vol. 169, No. 1-2, pp. 195–198
Publisher
Elsevier
Publication Date
March 1994
DOI
10.1016/0304-3940(94)90390-5
ISSN
0304-3940