Journal article
Opioid receptors in human neuroblastoma SH-SY5Y cells: Evidence for distinct morphine (μ) and enkephalin (δ) binding sites
Abstract
Human neuroblastoma SH-SY5Y cells exhibited a heterogeneous population of mu and delta types of opioid binding sites. These specific binding sites displayed the characteristic saturability, stereospecificity and reversibility, expected of a receptor. Scatchard analysis of [3H]-D-Ala2-D-Leu5-enkephalin (DADLE) in the presence of 10(-5) M D-Pro4-morphiceptin (to block the mu receptors) and the competitive displacement by various highly selective …
Authors
Kazmi SMI; Mishra RK
Journal
Biochemical and Biophysical Research Communications, Vol. 137, No. 2, pp. 813–820
Publisher
Elsevier
Publication Date
June 1986
DOI
10.1016/0006-291x(86)91152-6
ISSN
0006-291X