Journal article
EMT: Mechanisms and therapeutic implications
Abstract
Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in normal mammalian development for decades, and it has been proposed as a critical mechanism during cancer progression and metastasis. EMT is tightly regulated by several internal and external cues that orchestrate the shifting from an epithelial-like phenotype …
Authors
Singh M; Yelle N; Venugopal C; Singh SK
Journal
Pharmacology & Therapeutics, Vol. 182, , pp. 80–94
Publisher
Elsevier
Publication Date
February 2018
DOI
10.1016/j.pharmthera.2017.08.009
ISSN
0163-7258