Journal article
Skeletal Muscle Aging in F344BN F1-Hybrid Rats: I. Mitochondrial Dysfunction Contributes to the Age-Associated Reduction in VO2max
Abstract
Although mitochondrial DNA damage accumulates in aging skeletal muscles, how this relates to the decline in muscle mass-specific skeletal muscle aerobic function is unknown. We used a pump-perfused rat hind-limb model to examine maximal aerobic performance (VO(2max)) in young adult (YA; 8-9-month-old), late middle aged (LMA; 28-30-month-old) and senescent (SEN; 36-month-old) Fischer 344 x Brown Norway F1-hybrid rats at matched rates of …
Authors
Hagen JL; Krause DJ; Baker DJ; Fu MH; Tarnopolsky MA; Hepple RT
Journal
The Journals of Gerontology Series A, Vol. 59, No. 11, pp. 1099–1110
Publisher
Oxford University Press (OUP)
Publication Date
November 1, 2004
DOI
10.1093/gerona/59.11.1099
ISSN
1079-5006