The effect of CRF2R agonist on skeletal muscle in mdx and wildtype mice

Duchenne muscular dystrophy (DMD) is an X‐linked neuromuscular disease resulting in progressive muscle weakness. The mdx mouse is a mouse model of DMD, which lacks dystrophin protein. Corticotrophin releasing factors (CRF) are naturally occurring peptides that bind to a corticotrophin releasing factor receptor (CRFR). It has been reported that a corticotrophin releasing factor receptor 2 (CRF2R) agonist prevented muscle atrophy due to …