Journal article
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
Abstract
Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically characterized by centrally located nuclei, central aggregation of oxidative activity, and type I fiber predominance and hypotrophy. Here, we obtained commercially available mice overexpressing phospholamban (Pln(OE)), a well-known inhibitor of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs), in their slow-twitch type I skeletal muscle fibers to determine the …
Authors
Fajardo VA; Bombardier E; McMillan E; Tran K; Wadsworth BJ; Gamu D; Hopf A; Vigna C; Smith IC; Bellissimo C
Journal
Disease Models & Mechanisms, Vol. 8, No. 8, pp. 999–1009
Publisher
The Company of Biologists
Publication Date
January 1, 2015
DOI
10.1242/dmm.020859
ISSN
1754-8403