Journal article
A comparison of meta-analytic methods for synthesizing evidence from explanatory and pragmatic trials
Abstract
BackgroundThe pragmatic–explanatory continuum indicator summary version 2 (PRECIS-2) tool has recently been developed to classify randomized clinical trials (RCTs) as pragmatic or explanatory based on their design characteristics. Given that treatment effects in explanatory trials may be greater than those obtained in pragmatic trials, conventional meta-analytic approaches may not accurately account for the heterogeneity among the studies and …
Authors
Sajobi TT; Li G; Awosoga O; Wang M; Menon BK; Hill MD; Thabane L
Journal
Systematic Reviews, Vol. 7, No. 1,
Publisher
Springer Nature
Publication Date
12 2018
DOI
10.1186/s13643-017-0668-3
ISSN
2046-4053