Journal article
CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.
Abstract
Mycobacterium tuberculosis, the pathogen causing pulmonary tuberculosis (TB) in humans, has evolved to delay Th1 immunity in the lung. Although conventional dendritic cells (cDCs) are known to be critical to the initiation of T cell immunity, the differential roles and molecular mechanisms of migratory CD11b+ and CD103+ cDC subsets in anti-M. tuberculosis Th1 activation remain unclear. Using a murine model of pulmonary M. tuberculosis …
Authors
Lai R; Jeyanathan M; Afkhami S; Zganiacz A; Hammill JA; Yao Y; Kaushic C; Xing Z
Journal
The Journal of Immunology, Vol. 200, No. 5, pp. 1746–1760
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2018
DOI
10.4049/jimmunol.1701109
ISSN
0022-1767