Association of wheeze with lung function decline in children with sickle cell disease

Emerging evidence suggests that wheezing in children with sickle cell disease (SCD) is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive crises, independent of a diagnosis of asthma [1, 2]. We investigated the relationships of longitudinal pulmonary function decline with wheeze, asthma and atopy in a cohort of paediatric patients with SCD, using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire [3], skin prick testing (SPT) and airway nitric oxide (NO) measurements. Wheeze in children with sickle cell disease is associated with airflow limitation and lung function decline http://ow.ly/oyZQ30fXnQs