Journal article
Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: A comparative study in gene‐deficient mice
Abstract
OBJECTIVE: To investigate the involvement of proinflammatory and destructive mediators in oncostatin M (OSM)-induced joint pathology, using gene-deficient mice.
METHODS: An adenoviral vector expressing murine OSM was injected into the joints of naive wild-type mice and mice deficient for interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha (TNFalpha), or inducible nitric oxide synthase (iNOS). Reverse transcription-polymerase chain reaction …
Authors
de Hooge ASK; van de Loo FAJ; Bennink MB; Arntz OJ; Fiselier TJW; Franssen MJAM; Joosten LAB; van Lent PLEM; Richards CD; van den Berg WB
Journal
Arthritis & Rheumatism, Vol. 48, No. 6, pp. 1750–1761
Publisher
Wiley
Publication Date
6 2003
DOI
10.1002/art.10972
ISSN
0004-3591
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAdolescentAnimalsArthritis, JuvenileChildDisease Models, AnimalFemaleGene Transfer TechniquesGenetic VectorsGrowth PlateHumansInterleukin-1JointsMaleMiceMice, Inbred C57BLMice, KnockoutOncostatin MPeptidesProteoglycansRNA, MessengerReverse Transcriptase Polymerase Chain ReactionSynovial Fluid