Subpixel Enhancement of Nonuniform Tissue (SPENT): A Novel MRI Technique for Quantifying BMD*

BMD is commonly obtained with DXA, but this is confounded by the length and composition of tissues that the X-ray must traverse. Subpixel enhancement of nonuniform tissue (SPENT) is a novel MRI technique that can provide (direction specific) information based on the subvoxel structural uniformity of a sample. We hypothesized that the SPENT signal would be related to BMD. This hypothesis was tested using (1) 2D computer simulation of a …