Journal article
Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders
Abstract
Chronic overnutrition and a sedentary lifestyle promote imbalances in metabolism, often manifesting as risk factors for life-threating diseases such as atherosclerotic cardiovascular disease (ASCVD) and nonalcoholic fatty liver disease (NAFLD). Nucleocytosolic acetyl-coenzyme A (CoA) has emerged as a central signaling node used to coordinate metabolic adaptations in response to a changing nutritional status. ATP-citrate lyase (ACL) is the …
Authors
Pinkosky SL; Groot PHE; Lalwani ND; Steinberg GR
Journal
Trends in Molecular Medicine, Vol. 23, No. 11, pp. 1047–1063
Publisher
Elsevier
Publication Date
11 2017
DOI
10.1016/j.molmed.2017.09.001
ISSN
1471-4914