Journal article
Adjunctive Use of Direct Thrombin Inhibitors in Patients Receiving Fibrinolytic Therapy for Acute Myocardial Infarction
Abstract
The direct thrombin inhibitors hirudin and bivalirudin inhibit both fluid-phase and clot-bound thrombin. These agents have been extensively studied in clinical trials in comparison with intravenous unfractionated heparin (UFH), as adjuncts to fibrinolytic therapy for ST-elevation myocardial infarction (STEMI) and in percutaneous coronary intervention (PCI), and they are currently undergoing further evaluation in patients with non-ST elevation …
Authors
French JK; Edmond JJ; Gao W; White HD; Eikelboom JW
Journal
American Journal of Cardiovascular Drugs, Vol. 4, No. 2, pp. 107–115
Publisher
Springer Nature
Publication Date
March 2004
DOI
10.2165/00129784-200404020-00004
ISSN
1175-3277