Journal article
Severe Injury Is Associated With Insulin Resistance, Endoplasmic Reticulum Stress Response, and Unfolded Protein Response
Abstract
OBJECTIVE: We determined whether postburn hyperglycemia and insulin resistance are associated with endoplasmic reticulum (ER) stress/unfolded protein response (UPR) activation leading to impaired insulin receptor signaling.
BACKGROUND: Inflammation and cellular stress, hallmarks of severely burned and critically ill patients, have been causally linked to insulin resistance in type 2 diabetes via induction of ER stress and the UPR.
Authors
Jeschke MG; Finnerty CC; Herndon DN; Song J; Boehning D; Tompkins RG; Baker HV; Gauglitz GG
Journal
Annals of Surgery, Vol. 255, No. 2, pp. 370–378
Publisher
Wolters Kluwer
Publication Date
February 2012
DOI
10.1097/sla.0b013e31823e76e7
ISSN
0003-4932
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentBlood GlucoseBurnsCase-Control StudiesCatecholaminesChildChild, PreschoolCytokinesElectrophoresis, Polyacrylamide GelEndoplasmic Reticulum StressFemaleGene Expression ProfilingHumansHydrocortisoneHyperglycemiaImmunoblottingInsulinInsulin ResistanceLeukocytesMaleOligonucleotide Array Sequence AnalysisProteomeUnfolded Protein Response