Journal article
White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms
Abstract
This study examined the impact of childhood neglect, serotonin transporter (5-HTTLPR) and brain derived neurotrophic factor (BDNF) polymorphisms on white matter (WM) integrity in major depressive disorder (MDD) using diffusion tensor imaging (DTI). Fifty-five medication-free MDD patients and 18 controls underwent diffusion tensor imaging scanning, genotyping and completed the Childhood Trauma Questionnaire. Tract based spatial statistics (TBSS) …
Authors
Tatham EL; Ramasubbu R; Gaxiola-Valdez I; Cortese F; Clark D; Goodyear B; Foster J; Hall GB
Journal
Psychiatry Research Neuroimaging, Vol. 253, , pp. 15–25
Publisher
Elsevier
Publication Date
7 2016
DOI
10.1016/j.pscychresns.2016.04.014
ISSN
0925-4927