Journal article
Modifications in Perfringolysin O Domain 4 Alter the Cholesterol Concentration Threshold Required for Binding
Abstract
Changes in the cholesterol content of cell membranes affect many physiological and pathological events, including the formation of arterial plaques, the entry of virus into cells, and receptor organization. Measuring the trafficking and distribution of cholesterol is essential to understanding how cells regulate sterol levels in membranes. Perfringolysin O (PFO) is a cytolysin secreted by Clostridium perfringens that requires cholesterol in the …
Authors
Johnson BB; Moe PC; Wang D; Rossi K; Trigatti BL; Heuck AP
Journal
Biochemistry, Vol. 51, No. 16, pp. 3373–3382
Publisher
American Chemical Society (ACS)
Publication Date
April 24, 2012
DOI
10.1021/bi3003132
ISSN
0006-2960