Presence and bioavailability of bisphenol A in the uterus of rats and mice following single and repeated dietary administration at low doses

This research examined the distribution of low dietary doses of bisphenol A (BPA). When female rats received 50μg/kg (14)C-BPA orally, radioactivity was distributed throughout the body, with especial presence in the uterus. Pre-treatment with estradiol or the estrogen antagonist ICI 182,780 significantly reduced radioactivity in the uterus. The majority of BPA at the uterus was determined to be aglycone (receptor-active) via GC-MS. …