Calculation of the Response of Field-Effect Transistors to Charged Biological Molecules

Robust approximations are presented that allow for the simple calculation of the total charge and potential drop psi0 across the region of electrolyte containing charged biological macromolecules that are attached to the gate area of a field-effect transistor (FET). The attached macromolecules are modeled as an ion-permeable membrane in contact with the insulator surface, exchanging protons with the electrolyte as described by the site-binding …