Journal article
Analog binding to melatonin receptors in chick brain: Effects of GTP and prazosin
Abstract
2-[125I]Iodomelatonin binding studies were carried out in chick brain membranes to compare the high-affinity melatonin receptor pharmacology of various 2-phenylmelatonin-based compounds, the naphthalenic agonist S-20098, and melatonin. Competition binding studies with 2-phenylmelatonin revealed a single class of binding sites with an inhibitory constant (K(i)) of 186 ± 8.31 pM that failed to show any change in the presence of GTP (K(i) = 200 ± …
Authors
Neu J; Niles LP; Brough PA; Chen JJ; Snieckus V; Firnau G
Journal
Medicinal Chemistry Research, Vol. 10, No. 2, pp. 114–121
Publication Date
January 1, 2000
ISSN
1054-2523