Journal article
Heat-shock enhanced reactivation of a UV-damaged reporter gene in human cells involves the transcription coupled DNA repair pathway
Abstract
A recombinant nonreplicating human adenovirus type 5, Ad5HCMVsp1lacZ, expressing the lacZ gene under control of the human cytomegalovirus immediate early promoter, was used to assess the effect of heat-shock (HS) on DNA repair of a UV-damaged reporter gene. Host cell reactivation (HCR) of beta-galactosidase (beta-gal) activity for UV-irradiated Ad5HCMVsp1lacZ was used as an indicator of DNA repair in the transcribed strand of an active gene. …
Authors
McKay BC; Rainbow AJ
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 363, No. 2, pp. 125–135
Publisher
Elsevier
Publication Date
June 1996
DOI
10.1016/0921-8777(96)00013-4
ISSN
0027-5107