Journal article
UV-inducible base excision repair of oxidative damaged DNA in human cells
Abstract
Methylene blue (MB) acts as a photosensitizer and after excitation by visible light (VL) produces reactive oxygen species that result in oxidatively damaged DNA. (MB + VL) produces predominantly 8-hydroxyguanine as well as other single base modifications in DNA that are repaired by base excision repair (BER). We have used a recombinant non-replicating human adenovirus, Ad5HCMVlacZ, which expresses the beta-galactosidase (beta-gal) reporter …
Authors
Kassam SN; Rainbow AJ
Journal
Mutagenesis, Vol. 24, No. 1, pp. 75–83
Publisher
Oxford University Press (OUP)
Publication Date
January 2009
DOI
10.1093/mutage/gen054
ISSN
0267-8357