Dynamics of interactions between human albumin and polyethylene surface

The adsorption of human albumin to polyethylene was studied using radioiodinated (125I or 131I) protein. Adsorption at 23°C under laminar flow conditions over a range of shear rates up to 2500 sec−1 and from 0.1 to 3.8 mg ml−1 was investigated. A steady-state surface concentration (SSSC) was reached within 2–3 hr under all conditions. The value of SSSC was independent of flow conditions. Concentration dependence followed a Langmuir-like …