Fibrinogen and albumin adsorption from human blood plasma and from buffer onto chemically functionalized silica substrates

Monolayers of silanes having a variety of chemical functionality were attached to pure silica tubes or plates. These model surfaces were characterized by X-ray photoelectron spectroscopy and advancing water contact angles. The adsorption of albumin and fibrinogen to these surfaces was studied using the radioiodinated proteins. In single protein systems neither albumin nor fibrinogen adsorption was found to be strongly correlated with …