THU0498 Increase of CXCR3-CCR4+CCR6+CCR10- Memory T Helper Cells (TH17-LIKE) in Patients with Granulomatosis and Polyangiitis (GPA)

Background Granulomatosis and polyangiitis (GPA) is a systemic vasculitis associated with anti-proteinase-3 antibodies and T-cell activation. Recruitment of memory T-cells into inflammatory sites depends on chemokine receptors and their specific patterns shape functional properties (e.g. cytokine production) of T helper-cells. Methods We analyzed subtypes of peripheral blood CD4+ memory (CD45RA-) T-cells identified by the expression of CCR7, …