Folate-sensitive fragile sites in schizophrenia and bipolar disorder: Candidate regions for susceptibility loci?

The discovery of trinucleotide repeat expansion as a disorder-causing mutation mechanism in >10 conditions associated with neurodevelopmental abnormalities and/or neurodegeneration provides an alternative to candidate gene testing and linkage studies to search for genes of major effect in neuropsychiatric disorders. Based on the finding that five rare folate-sensitive chromosomal fragile sites have been shown to result from large expansions of …