Abstract 1302: Effect of intestinal-specific Kaiso overexpression on the APC MIN/+ mouse colon cancer model

Abstract The canonical Wnt signaling pathway is a crucial regulator of various cellular processes during embryogenesis but when aberrantly activated, it leads to tumorigenesis. The key downstream effector of the Wnt pathway is the Armadillo protein, β-catenin, which was first characterized as a cytoplasmic cofactor for the transmembrane, cell-cell adhesion tumor suppressor, E-cadherin. Recent evidence from our lab and others …