Journal article
Regulation of the Rapsyn Promoter by Kaiso and δ-Catenin
Abstract
Rapsyn is a synapse-specific protein that is required for clustering acetylcholine receptors at the neuromuscular junction. Analysis of the rapsyn promoter revealed a consensus site for the transcription factor Kaiso within a region that is mutated in a subset of patients with congenital myasthenic syndrome. Kaiso is a POZ-zinc finger family transcription factor which recognizes the specific core consensus sequence CTGCNA (where N is any …
Authors
Rodova M; Kelly KF; VanSaun M; Daniel JM; Werle MJ
Journal
Molecular and Cellular Biology, Vol. 24, No. 16, pp. 7188–7196
Publisher
Taylor & Francis
Publication Date
August 1, 2004
DOI
10.1128/mcb.24.16.7188-7196.2004
ISSN
0270-7306
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Active Transport, Cell NucleusAnimalsAntibiotics, AntineoplasticArmadillo Domain ProteinsBase SequenceCateninsCell Adhesion MoleculesCell LineChickensCytoskeletal ProteinsFatty Acids, UnsaturatedGene Expression RegulationGenes, ReporterHumansMacromolecular SubstancesMiceMolecular Sequence DataMuscle Fibers, SkeletalMuscle ProteinsMuscle, SkeletalMyasthenic Syndromes, CongenitalNeuromuscular JunctionPhosphoproteinsPromoter Regions, GeneticSequence AlignmentTranscription FactorsDelta Catenin