22 NOD2 immunity protects against obesity-induced inflammation and insulin resistance

AimsObesity is associated with immune cell infiltration and inflammation in metabolic tissues that contributes to insulin resistance. Pattern recognition receptors (PRRs) link obesity-induced inflammation and insulin resistance. Nucleotide oligomerization domain protein 2 (NOD2) is a PRR that detects muramyl dipeptide (MDP) present in the cell walls of all bacteria. NOD2 mutations are associated with inflammatory bowel disease, and NOD2 …