Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups.

OBJECTIVE: To assess independent predictors of hemorrhage in 651 anticoagulated patients. BACKGROUND: An excess incidence of major bleeding (7% per year) in patients with nondisabling cerebral ischemia of presumed arterial origin treated with oral anticoagulation led to early termination of the Stroke Prevention In Reversible Ischemia Trial (SPIRIT). METHODS: The relationship between known risk factors and hemorrhage was assessed by univariate …