Journal article
Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair
Abstract
Background:Hypoxia-inducible factor (HIF1A) regulates the myocardial response to hypoxia and hemodynamic load. We investigated the association of HIF1A variants with right-ventricular (RV) remodeling after tetralogy of Fallot (TOF) repair.Methods:Children with TOF were genotyped for three single-nucleotide polymorphisms in HIF1A. Genotypes were analyzed for association with RV myocardial protein expression and fibrosis at complete repair (n = …
Authors
Jeewa A; Manickaraj AK; Mertens L; Manlhiot C; Kinnear C; Mondal T; Smythe J; Rosenberg H; Lougheed J; McCrindle BW
Journal
Pediatric Research, Vol. 72, No. 4, pp. 407–413
Publisher
Springer Nature
Publication Date
10 2012
DOI
10.1038/pr.2012.95
ISSN
0031-3998
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptation, PhysiologicalAngiogenic ProteinsCardiac Surgical ProceduresChild, PreschoolFibrosisFollow-Up StudiesGene FrequencyGenotypeHeart VentriclesHumansHypertrophy, Right VentricularHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInfantKaplan-Meier EstimateLinear ModelsLogistic ModelsPhenotypePolymorphism, Single NucleotideProspective StudiesRegistriesReoperationTetralogy of FallotTime FactorsTransforming Growth Factor beta1Treatment OutcomeVentricular Dysfunction, RightVentricular Remodeling