Journal article
Three-dimensional computed tomography imaging in an animal model of emphysema
Abstract
Emphysema is a major health problem and novel drugs are needed. Animal disease models are pivotal in their development, but the validity and sensitivity of current tools for the evaluation of drug efficacy is limited. The usefulness of micro computed tomography (CT) as an innovative tool to assess emphysema in a mouse model was investigated. Serial CT scans were performed in bi-weekly intervals in Smad3 knockout (KO) mice, which spontaneously …
Authors
Froese AR; Ask K; Labiris R; Farncombe T; Warburton D; Inman MD; Gauldie J; Kolb M
Journal
European Respiratory Journal, Vol. 30, No. 6, pp. 1082–1089
Publisher
European Respiratory Society (ERS)
Publication Date
12 2007
DOI
10.1183/09031936.00000507
ISSN
0903-1936