Journal article
Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas
Abstract
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E mutated PLGG (n = 99) were compared …
Authors
Lassaletta A; Zapotocky M; Mistry M; Ramaswamy V; Honnorat M; Krishnatry R; Guerreiro Stucklin A; Zhukova N; Arnoldo A; Ryall S
Journal
Journal of Clinical Oncology, Vol. 35, No. 25,
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
September 1, 2017
DOI
10.1200/jco.2016.71.8726
ISSN
0732-183X