Journal article
Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor
Abstract
The M358R variant of alpha-1-proteinase inhibitor (API) is a potent soluble inhibitor of thrombin. Previously we engineered AR-API M358R, a membrane-bound form of this protein and showed that it inhibited exogenous thrombin when expressed on transfected cells lacking tissue factor (TF). To determine the suitability of AR-API M358R for gene transfer to vascular cells to limit thrombogenicity, we tested the ability of AR-API M358R to inhibit …
Authors
Gierczak RF; Pepler L; Bhagirath V; Liaw PC; Sheffield WP
Journal
Thrombosis Research, Vol. 134, No. 5, pp. 1142–1149
Publisher
Elsevier
Publication Date
November 2014
DOI
10.1016/j.thromres.2014.09.002
ISSN
0049-3848