selected scholarly activity
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chapters
- Quinoxaline Chemistry: Developments 1963-1975. Advances in Heterocyclic Chemistry. 367-431. 1978
- Recent Advances in Pyazine Chemistry. Advances in Heterocyclic Chemistry. 99-209. 1972
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conferences
- AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal injury in rats.. Journal of Neurotrauma. 1305-1305. 2004
- Guanosine induces remyelination and improves functional outcome after spinal cord injury. Journal of Neurotrauma. 1305-1305. 2004
- Guanosine promotes remyelination and functional recovery in chronic spinal. Journal of Neurotrauma. 1081-1081. 2003
- Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor‐mediated mechanisms. Drug Development Research. 303-315. 2001
- PEROXIDE INHIBITS ANG-II RESPONSES IN PIG CORONARY-ARTERY. The FASEB Journal. A598-A598. 1994
- NEURO-ENDOCRINE AND NEUROBIOCHEMICAL RESPONSES AS A PROBE INTO THE MECHANISMS OF ACTION OF ECT. Neuroendocrinology Letters. 280-280. 1988
- BIOLOGICAL RHYTHMS, MELATONIN AND DEPRESSION. Journal of Neural Transmission. 488-489. 1986
- H-3 CLONIDINE BINDING TO MEMBRANES OF PLATELETS OF DEPRESSED-PATIENTS BEFORE AND AFTER TREATMENT. International Journal of Neuroscience. 128-128. 1986
- TREATMENT EFFECTS ON H-3 CLONIDINE BINDING TO PLATELET MEMBRANES IN DEPRESSED-PATIENTS. Clinical and Investigative Medicine. A115-A115. 1986
- INVITRO TREATMENT OF HUMAN-PLATELETS WITH DESMETHYLIMIPRAMINE ALTERS BINDING-PROPERTIES OF THE ALPHA-2 ADRENOCEPTOR. Clinical and Investigative Medicine. A159-A159. 1985
- THE EFFECT OF ELECTROCONVULSIVE-THERAPY ON ALPHA-2 RECEPTORS IN PLATELETS FROM DEPRESSED-PATIENTS. Clinical and Investigative Medicine. A157-A157. 1985
- Effect of lithium on 24 hour pattern of serum and pineal melatonin in pigmented eye rats. Journal of Steroid Biochemistry and Molecular Biology. 1465-1465. 1984
- PHLORETIN-SENSITIVE LITHIUM TRANSPORT IN ERYTHROCYTES OF AFFECTIVELY ILL PATIENTS - INTRA-INDIVIDUAL REPRODUCIBILITY. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 318-319. 1981
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journal articles
- MPP+-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine. Purinergic Signalling. 3:399-409. 2007
- Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation. European Journal of Pharmacology. 560:17-22. 2007
- Non-adenine based purines accelerate wound healing. Purinergic Signalling. 2:651-661. 2006
- P2X7Receptor Activation in Rat Brain Cultured Astrocytes Increases the Biosynthetic Release of Cysteinyl Leukotrienes. International Journal of Immunopathology and Pharmacology. 18:417-430. 2005
- Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP. Purinergic Signalling. 1:161-172. 2005
- Acceleration of blood-brain barrier formation after transplantation of enteric glia into spinal cords of rats. Experimental Brain Research. 162:56-62. 2005
- Ait-082 and Methylprednisolone Singly, but Not in Combination, Enhance Functional and Histological Improvement after Acute Spinal Cord Injury in Rats. International Journal of Immunopathology and Pharmacology. 17:353-366. 2004
- The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes. Glia. 46:356-368. 2004
- Guanosine protects SH-SYSY cells against beta-amyloid-induced apoptosis. NeuroReport. 15:833-836. 2004
- Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis. NeuroReport. 15:833-836. 2004
- Guanosine promotes myelination and functional recovery in chronic spinal injury. NeuroReport. 14:2463-2467. 2003
- Enteric glia promote functional recovery of CTM reflex after dorsal root transection. NeuroReport. 14:1301-1304. 2003
- Enteric glia promote functional recovery of CTM reflex after dorsal root transection. NeuroReport. 14:1301-1304. 2003
- Enteric glia promote regeneration of transected dorsal root axons into spinal cord of adult rats. Experimental Neurology. 181:79-83. 2003
- Mechanisms of apoptosis induced by purine nucleosides in astrocytes. Glia. 38:179-190. 2002
- Specific [3H]‐guanosine binding sites in rat brain membranes. British Journal of Pharmacology. 135:969-976. 2002
- Characterization of specific GTP binding sites in C2C12 mouse skeletal muscle cells.. Journal of Muscle Research and Cell Motility. 23:107-118. 2002
- The role of 3'-untranslated region (3'-UTR) mediated mRNA stability in cardiovascular pathophysiology.. Molecular and Cellular Biochemistry. 224:53-67. 2001
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Functional AT
1- , and α-adrenoceptors in cultured smooth muscle cells from WKY and SHR rats. Biomedical Research. 11:163-171. 2000 - Nifedipine induces apoptosis in cultured vascular smooth muscle cells from spontaneously hypertensive rats. Life Sciences. 67:895-906. 2000
- Vascular β-adrenoceptor function in hypertension and in ageing. Canadian Journal of Physiology and Pharmacology. 78:433-452. 2000
- Effects of electroconvulsive therapy and desipramine on neuroendocrine responses to the clonidine challenge test.. Journal of Psychiatry & Neuroscience. 23:172-178. 1998
- Cross-over study comparing effects of treatment with an angiotensin converting enzyme inhibitor and an angiotensin II type 1 receptor antagonist on cardiovascular changes in hypertension. Journal of Hypertension. 16:477-486. 1998
- Antihypertensive effects of perindopril treatment in adult spontaneously hypertensive rats.. Canadian Journal of Cardiology. 13:831-835. 1997
- Expression of functional β-adrenoceptors and polyploidy development in cultured vascular smooth muscle cells from spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology. 75:375-382. 1997
- Effects of Electroconvulsive Therapy on Peripheral Adrenoceptors, Plasma, Noradrenaline, MHPG and Cortisol in Depressed Patients. The British journal of psychiatry. Supplement. 169:758-765. 1996
- EFFECTS OF PEROXIDE AND SUPEROXIDE ON CORONARY-ARTERY - ANG-II RESPONSE AND SARCOPLASMIC-RETICULUM CA2+ PUMP. American Journal of Physiology - Cell Physiology. 269:C546-C553. 1995
- Effects of peroxide and superoxide on coronary artery: ANG II response and sarcoplasmic reticulum Ca2+ pump. American Journal of Physiology. 269:C546-C553. 1995
- Abstracts. Canadian Journal of Anaesthesia. 41:A3-A76. 1994
- Platelet α2-Adrenergic Receptors in Depressed Patients and Healthy Volunteers: The Effects of Desipramine. Pharmacopsychiatry. 25:199-206. 1992
- Studies on leukocyte β-adrenergic receptors in depression: A critical appraisal. Life Sciences. 47:85-105. 1990
- Lithium and rhythms of beta-adrenergic ([3H]CGP-12177) binding in intact rat retina, pineal gland, and hypothalamus. Biological Psychiatry. 22:1191-1200. 1987
- Dysregulation of neuroendocrine crossroads: Depression, orcadian rhythms and the retina — A hypothesis. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 11:267-278. 1987
- Lithium and circadian patterns of melatonin in the retina, hypothalamus, pineal and serum. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 11:325-334. 1987
- 3H-Clonidine binding to membranes of platelets prepared under physiological conditions. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 9:579-583. 1985
- Lithium and twenty-four hour rhythms of serum corticosterone, prolactin and growth hormone in pigmented eye rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 9:755-758. 1985
- Erythrocyte lithium efflux in bipolar patients and control subjects: The question of reproducibility. Psychiatry Research. 13:175-185. 1984
- Erythrocyte Lithium Transport in Bipolar Affective Disorders. Neuropsychobiology. 12:86-92. 1984
- Lithium and melatonin in pigmented eye rats: Effects of dose and time of day. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 8:733-736. 1984
- Lithium in pigmented eye rats: Effects of dose and time of day on drinking, body weight, retinal and blood distribution. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 8:765-768. 1984
- Chronic lithium treatment and twenty-four hour rhythm of serum prolactin, growth hormone and melatonin in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 7:827-830. 1983
- Effect of combined haloperidol-lithium treatment on in vitro RBC lithium uptake in patients with affective disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 7:831-834. 1983
- Effect of chronic lithium treatment on twenty four hour variation in plasma and red blood cell lithium and sodium concentrations, drinking behavior, body weight, kidney weight, and corticosterone levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 6:455-458. 1982
- Phloretin-sensitive lithium transport in erythrocytes of affectively ill patients: Intra-individual reproducibility. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 5:503-506. 1981
- ChemInform Abstract: QUINOXALINE CHEMISTRY. DEVELOPMENTS 1963‐1975. ChemInform. 9:no-no. 1978
- Altered lipoprotein composition and elevated serum lipids in chicken embryos with hereditary muscular dystrophy. Neuroscience Letters. 8:151-158. 1978
- Elevated cholesterol in tissues of chicken embryos with hereditary myotonic muscular dystrophy. Experimental Neurology. 57:475-485. 1977
- ChemInform Abstract: OLIGORIBONUCLEOTIDE SYNTHESIS. X. AN IMPROVED SYNTHESIS OF THE ANTICODON LOOP P REGION OF METHIONINE TRANSFER RIBONUCLEIC ACID FROM E. COLI. ChemInform. 7:no-no. 1976
- Oligoribonucleotide synthesis. X. An improved synthesis of the anticodon loop region of methionine transfer ribonucleic acid from E. coli. Canadian Journal of Chemistry. 54:2689-2696. 1976
- ChemInform Abstract: OLIGORIBONUCLEOTIDE SYNTHESIS PART 8, INSERTION OF TERMINAL 5′‐PHOSPHATE GROUPINGS. ChemInform. 6:no-no. 1975
- Oligoribonucleotide Synthesis. VIII. Insertion of Terminal 5′-Phosphate Groupings. Canadian Journal of Chemistry. 53:1093-1098. 1975
- ChemInform Abstract: OLIGORIBONUCLEOTIDE SYNTHESIS PART 7, SYNTHESIS OF THE ANTICODON LOOP OF ESCHERICHIA COLI METHIONINE TRANSFER RIBONUCLEIC ACID. ChemInform. 5:no-no. 1974
- ChemInform Abstract: OLIGORIBONUCLEOTIDE SYNTHESIS PART 6, SELECTIVE DEBLOCKING OF THE 5′‐O‐TRIPHENYLMETHOXYACETYL GROUPING IN PROTECTED DINUCLEOTIDES. ChemInform. 4:no-no. 1973
- ChemInform Abstract: OLIGORIBONUCLEOTID‐SYNTH. 5. MITT. DARST. VON 2′‐O‐TETRAHYDROPYRANYL‐DERIVATEN VON GUANOSIN UND IHRE EINFUEGUNG IN EINE ALLGEMEINE STUFEN‐SYNTH.. ChemInform. 4:no-no. 1973
- Oligoribonucleotide Synthesis. VI. Selective Deblocking of the 5′-O-Triphenylmethoxyacetyl Grouping in Protected Dinucleotides. Canadian Journal of Chemistry. 51:1889-1892. 1973
- Oligoribonucleotide Synthesis. V. Preparation of 2′-O-Tetrahydropyranyl Derivatives of Guanosine and Their Insertion into a General Stepwise Synthesis. Canadian Journal of Chemistry. 51:1068-1074. 1973
- ChemInform Abstract: NEUERE FORTSCHRITTE IN DER PYRAZINCHEMIE. ChemInform. 3:no-no. 1972
- ChemInform Abstract: OLIGORIBONUCLEOTID‐SYNTH. 4. MITT. WEG ZUR BLOCK‐SYNTH.. ChemInform. 3:no-no. 1972
- Oligoribonucleotide Synthesis. IV. Approach to Block Synthesis. Canadian Journal of Chemistry. 50:1283-1291. 1972
- ChemInform Abstract: OLIGORIBONUCLEOTID‐SYNTH. 3. MITT. SYNTH. VON TRINUCLEOTIDEN UNTER VERWENDUNG EINER STUFENWEISEN PHOSPHOTRIESTER‐METHODE. Chemischer Informationsdienst Organische Chemie. 2:no-no. 1971
- Conversion of N6-(Δ2-Isopentenyl)adenosine to Adenosine by Enzyme Activity in Tobacco Tissue. Plant Physiology. 48:775-778. 1971
- Oligoribonucleotide Synthesis III. Synthesis of Trinucleotides Using a Stepwise Phosphotriester Method. Canadian Journal of Chemistry. 49:3004-3011. 1971
- ChemInform Abstract: OLIGORIBONUCLEOTID‐SYNTH. 2. MITT. DARST. VON 2′‐O‐TETRAHYDROPYRANYL‐DERIVATEN VON ADENOSIN UND CYTIDIN, DIE ZUR STUFENWEISEN SYNTH. BENOETIGT WERDEN. Chemischer Informationsdienst Organische Chemie. 2:no-no. 1971
- Oligoribonucleotide Synthesis. II. Preparation of 2′-O-tetrahydropyranyl Derivatives of Adenosine and Cytidine Necessary for Insertion in Stepwise Synthesis. Canadian Journal of Chemistry. 49:493-499. 1971