selected scholarly activity
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books
- MUNE in ALS: natural history and implications. Ed. 55. 2003
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conferences
- Polymerase gamma mutator mice rely on increased glycolytic flux for energy production. Mitochondrion. 19-26. 2015
- MUNE in ALS: natural history and implications. Supplements to Clinical neurophysiology. 167-176. 2003
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journal articles
- Rare neurovascular genetic and imaging markers across neurodegenerative diseases. Alzheimer's and Dementia. 19:5583-5595. 2023
- Assessing the Measurement Properties of the Self-Administered Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised (ALSFRS-R): A Rasch Analysis. Physical Therapy. 103:pzad109. 2023
- White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases. Alzheimer's Research and Therapy. 15:114. 2023
- Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function. Canadian Journal of Psychiatry. 68:347-358. 2023
- Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases. Brain Communications. 5:fcad049. 2023
- Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort. Alzheimer's and Dementia. 19:226-243. 2023
- Refining items for a preference-based, amyotrophic lateral sclerosis specific, health-related quality of life scale. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 23:508-516. 2022
- Targeted copy number variant identification across the neurodegenerative disease spectrum. Molecular genetics & genomic medicine. 10:e1986. 2022
- Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario neurodegenerative disease research initiative. International Journal of Geriatric Psychiatry. 37. 2022
- Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases. GeroScience. 44:1575-1598. 2022
- Small and Large Magnetic Resonance Imaging–Visible Perivascular Spaces in the Basal Ganglia of Parkinson's Disease Patients. Movement Disorders. 37:1304-1309. 2022
- MN-166 (ibudilast) in Amyotrophic Lateral Sclerosis in a Phase IIb/III Study: COMBAT-ALS Study Design. Neurodegenerative Disease Management. 11:431-443. 2021
- Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Neurology. 20:821-831. 2021
- Contribution of rare variant associations to neurodegenerative disease presentation. npj Genomic Medicine. 6:80. 2021
- Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses. Neurobiology of Aging. 105:378.e1-378.e9. 2021
- MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease. Sleep Medicine. 83:83-88. 2021
- Do Generic Preference-Based Measures Accurately Capture Areas of Health-Related Quality of Life Important to Individuals with Amyotrophic Lateral Sclerosis: A Content Validation Study. Patient Related Outcome Measures. Volume 12:191-203. 2021
- Sodium Phenylbutyrate–Taurursodiol for ALS. New England Journal of Medicine. 383:2293-2294. 2020
- Neuropsychiatric symptom burden across neurodegenerative disorders and its association with function. Alzheimer's and Dementia. 16. 2020
- Reappraisal of an ALS trial: unaccounted procedural risk. Lancet Neurology. 19:717-718. 2020
- Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures. Frontiers in Neurology. 11:847. 2020
- A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20:584-594. 2019
- Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative. Canadian Journal of Neurological Sciences. 46:491-498. 2019
- Author response to a Letter to the Editor entitled: Edaravone administration in pivotal clinical study 19 (Authors: Genge, Angela; Brooks, Benjamin). Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20:300-302. 2019
- Is edaravone harmful? (A placebo is not a control). Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19:477-482. 2018
- Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease. Journal of Visualized Experiments. 2018. 2018
- Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis. NeuroReport. 28:141-148. 2017
- Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function. PLoS ONE. 12:e0171668-e0171668. 2017
- Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice. Histochemistry and Cell Biology. 145:545-559. 2016
- Why is ALS so Difficult to Treat?. Canadian Journal of Neurological Sciences. 41:144-155. 2014
- Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice. BMC Neuroscience. 14:119. 2013
- Sonic Hedgehog is Cytoprotective against Oxidative Challenge in a Cellular Model of Amyotrophic Lateral Sclerosis. Journal of Molecular Neuroscience. 47:31-41. 2012
- Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice. BMC Neuroscience. 12:71. 2011
- Lack of Effect of Methylene Blue in the SOD1 G93A Mouse Model of Amyotrophic Lateral Sclerosis. PLoS ONE. 6:e23141-e23141. 2011
- Effects of Acute Exposure to Aluminum on Cognition in Humans. Journal of Toxicology and Environmental Health - Part A. 70:2011-2019. 2007
- Phase II/III randomized trial of TCH346 in patients with ALS. Neurology. 69:776-784. 2007
- Competence and Cognitive Difficulty in Physicians: A Follow-up Study. Academic Medicine. 81:915-918. 2006
- A Study of the Purine Derivative AIT-082 in G93A SOD1 Transgenic Mice. International Journal of Immunopathology and Pharmacology. 19:489-498. 2006
- Contextual Considerations in Summative Competency Examinations: Relevance to the Long Case. Academic Medicine. 80:1133-1137. 2005
- Histological assessment of intermediate- and long-term creatine monohydrate supplementation in mice and rats. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 285:R762-R769. 2003
- Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice. Neuroscience. 119:661-667. 2003
- Multifocal motor neuropathy improved by IVIg. Neurology. 56:1608-1608. 2001
- Lasting impact in families after death from ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2:181-187. 2001
- Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice. Journal of the Neurological Sciences. 180:52-54. 2000
- Manganese Superoxide Dismutase Levels Are Elevated in a Proportion of Amyotrophic Lateral Sclerosis Patient Cell Lines. Biochemical and Biophysical Research Communications. 273:359-363. 2000
- Cognitive Difficulty in Physicians. Academic Medicine. 75:177-181. 2000
- Results of Remedial Continuing Medical Education in Dyscompetent Physicians. Academic Medicine. 75:174-176. 2000
- Bench to bedside in medical education. Academic Medicine. 74:664-6. 1999
- Electrical Stimulation of the Septal Region of Aged Rats Improves Performance in an Open-Field Maze. Physiology and Behavior. 62:1279-1282. 1997
- The effect of presentation order in clinical decision making. Academic Medicine. 72:S40???2-S40???2. 1997
- The effect of presentation order in clinical decision making. Academic Medicine. 72:S40-S42. 1997
- Temporal arteritis and polymyalgia rheumatica. Neurology. 46:901-906. 1996
- Reply from the author:. Canadian Journal of Neurological Sciences. 22:76-76. 1995
- Hippocampal Stimulation of Fornical-lesioned Rats Improves Working Memory. Canadian Journal of Neurological Sciences. 21:100-103. 1994
- Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease. Journal of Visualized Experiments.