selected scholarly activity
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journal articles
- Machine learning in preclinical drug discovery. Nature Chemical Biology. 20:960-973. 2024
- Discovery of antibiotics that selectively kill metabolically dormant bacteria. Cell Chemical Biology. 31:712-728.e9. 2024
- Generative AI for designing and validating easily synthesizable and structurally novel antibiotics. Nature Machine Intelligence. 6:338-353. 2024
- Discovery of a structural class of antibiotics with explainable deep learning. Nature. 626:177-185. 2024
- Applications of machine learning in microbial natural product drug discovery. Expert Opinion on Drug Discovery. 18:1259-1272. 2023
- Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii. Nature Chemical Biology. 19:1342-1350. 2023
- Antibiotic discovery in the artificial intelligence era. Annals of the New York Academy of Sciences. 1519:74-93. 2023
- A brief guide to machine learning for antibiotic discovery. Current Opinion in Microbiology. 69:102190-102190. 2022
- Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions. Molecular Cell. 82:3499-3512.e10. 2022
- Deep learning identifies synergistic drug combinations for treating COVID-19. Proceedings of the National Academy of Sciences of the United States of America. 118:e2105070118. 2021
- Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality. Nature Communications. 12:2321. 2021
- Clinically relevant mutations in core metabolic genes confer antibiotic resistance. Science. 371:eaba0862. 2021
- Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics. Cell Chemical Biology. 27:1544-1552.e3. 2020
- A Deep Learning Approach to Antibiotic Discovery. Cell. 181:475-483. 2020
- A Deep Learning Approach to Antibiotic Discovery. Cell. 180:688-702.e13. 2020
- Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate. Nature Microbiology. 4:2109-2117. 2019
- Bacterial Metabolism and Antibiotic Efficacy. Cell Metabolism. 30:251-259. 2019
- A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria. Nature Methods. 16:303-306. 2019
- Our Evolving Understanding of the Mechanism of Quinolones. Antibiotics. 7:32-32. 2018
- Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force. ACS Infectious Diseases. 4:382-390. 2018
- Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nature Communications. 9:458. 2018
- Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology. mBio. 8:e01977-e01916. 2017
- Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nature Microbiology. 2:17028. 2017
- A cell-based approach to characterize antimicrobial compounds through kinetic dose response. Bioorganic and Medicinal Chemistry. 24:6315-6319. 2016
- Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity. Cell Chemical Biology. 23:267-277. 2016
- Chemical modulators of ribosome biogenesis as biological probes. Nature Chemical Biology. 11:924-932. 2015
- Chemical Inhibition of Bacterial Ribosome Biogenesis Shows Efficacy in a Worm Infection Model. Antimicrobial Agents and Chemotherapy. 59:2918-2920. 2015
- Discovery of a small molecule that inhibits bacterial ribosome biogenesis. eLife. 3:e03574. 2014
- Predictors of Medication Compliance After Hospital Discharge in Adolescent Psychiatric Patients. Journal of Child and Adolescent Psychopharmacology. 8:133-141. 1998
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preprints