selected scholarly activity
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chapters
- Autoimmunity and Brain Dysfunction. 341-381. 2009
- Lupus as a model of neuroimmune interactions. NeuroImmune Biology. 379-386. 2001
- Brain, Behaviour and Lupus. 127-133. 1999
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conferences
- Age-Dependent Synthesis of Diverse Autoantibodies in the 3xTg-AD Model of Alzheimer's Disease. Journal of Immunology. 2020
- Early pathologies in the 3XTG-ad mouse model of Alzheimer's disease. Journal of Neurochemistry. 180-180. 2019
- [O1–14–05]: SEX‐SPECIFIC CHANGES IN SYSTEMIC IMMUNE STATUS AND CENTRAL PATHOLOGY IN 3XTG‐AD MICE. Alzheimer's and Dementia. p230-p230. 2017
- Multiple ANCA specificities in MRL/lpr mice. Clinical and Experimental Immunology. 125-125. 2011
- Autoimmunity, skin morphology and hair cycling in a mouse model of Systemic Lupus Erythematosus. Journal of Investigative Dermatology. S106-S106. 2010
- Brain-Reactive Autoantibodies and Brain Damage During Lupus-Like Disease. Biological Psychiatry. 70S-70S. 2009
- Olfactory Function and Neurogenesis in the MRL Model of Neuropsychiatric Lupus. Biological Psychiatry. 70S-70S. 2009
- The Refined Model of CNS Lupus. Biological Psychiatry. 69S-70S. 2009
- Identification of novel biomarkers of neuropsychiatric systemic lupus erythematosus. Clinical Chemistry. A73-A73. 2005
- Immunoglobulins in cytotoxic CSF from autoimmune mice. Journal of Neuroimmunology. 207-207. 2004
- Neuroanatomical and pharmacological evidence of dopaminergic system damage in Lupus-like disease. Journal of Neuroimmunology. 206-206. 2004
- Phenotype of infiltrating cells in brains of lupus-prone mice. Journal of Neuroimmunology. 72-72. 2004
- Quinpirole-induced self-injurious behaviour in autoimmune mice. Journal of Neuroimmunology. 139-139. 2004
- Mechanisms of neuronal damage in SLE and APLS: Therapeutic implications. Thrombosis Research. 630-630. 2004
- BEHAVIORAL DYSFUNCTION CORRELATES WITH THE ONSET OF AUTOIMMUNITY IN MRL-LPR MICE. Arthritis and Rheumatism. S355-S355. 1992
- Effect of phenobarbital on avoidance learning after prenatal exposure in the rat. Behavioural Brain Research. 143-143. 1986
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journal articles
- Gonadal Hormones Contribute to Sex Differences in Autoimmunity, Pathology and Behaviour in the 3×Tg‐AD Mouse Model of Alzheimer’s Disease. Alzheimer's and Dementia. 18. 2022
- Sex-Dependent Differences in Serum Autoantibody Levels in the 3×Tg-AD Model of Alzheimer’s Disease. Journal of Immunology. 208:108.14-108.14. 2022
- Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice. Alzheimer's Research and Therapy. 13:30. 2021
- Age-Dependent Synthesis of Diverse Autoantibodies in the 3xTg-AD Model of Alzheimer’s Disease. Journal of Immunology. 204:64.5-64.5. 2020
- Cerebrospinal fluid collection in laboratory mice: Literature review and modified cisternal puncture method. Journal of Neuroscience Methods. 311:402-407. 2019
- Early Intervention with a Multi-Ingredient Dietary Supplement Improves Mood and Spatial Memory in a Triple Transgenic Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease. 64:835-857. 2018
- Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice. Journal of Alzheimer's Disease. 63:1191-1205. 2018
- Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole. Behavioural Pharmacology. 29:211-224. 2018
- The MRL Model: A Valuable Tool in Studies of Autoimmunity-Brain Interactions. Methods in molecular biology (Clifton, N.J.). 1781:259-285. 2018
- Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling. Acta Neuropathologica Communications. 5:70. 2017
- Sustained Immunosuppression Alters Olfactory Function in the MRL Model of CNS Lupus. Journal of NeuroImmune Pharmacology. 12:555-564. 2017
- The water maze paradigm in experimental studies of chronic cognitive disorders: Theory, protocols, analysis, and inference. Neuroscience and Biobehavioral Reviews. 68:195-217. 2016
- Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST). Journal of Visualized Experiments. 2015. 2015
- Autoimmune Manifestations in the 3xTg-AD Model of Alzheimer's Disease. Journal of Alzheimer's Disease. 39:191-210. 2014
- Zoopharmacognosy in Diseased Laboratory Mice: Conflicting Evidence. PLoS ONE. 9:e100684-e100684. 2014
- Altered neuroendocrine status at the onset of CNS lupus-like disease. Brain, Behavior, and Immunity. 32:86-93. 2013
- P1–024: Immunological dysfunction and MCI‐like behavior in the 3xTgAD mice. Alzheimer's and Dementia. 9:p161-p161. 2013
- Effects of complete vagotomy and blockage of cell adhesion molecules on interferon-α induced behavioral changes in mice. Behavioural Brain Research. 240:1-10. 2013
- Anti-NMDA receptor encephalitis in children. Handbook of Clinical Neurology. 112:1229-1233. 2013
- Altered olfactory function in the MRL model of CNS lupus. Behavioural Brain Research. 234:303-311. 2012
- Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmunity Reviews. 11:863-872. 2012
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Effects of prolonged treatment with memantine in the
MRL model of central nervous system lupus. Clinical and Experimental Neuroimmunology. 3:116-128. 2012 - The MRL Model: An Invaluable Tool in Studies of Autoimmunity–Brain Interactions. Methods in molecular biology (Clifton, N.J.). 934:277-299. 2012
- Autoimmune and inflammatory mechanisms of CNS damage. Progress in Neurobiology. 95:301-333. 2011
- Autoimmunity as a principal pathogenic factor in the refined model of neuropsychiatric lupus. Clinical and Experimental Neuroimmunology. 1:141-152. 2010
- Intrathecal antibodies and brain damage in autoimmune MRL mice. Brain, Behavior, and Immunity. 24:289-297. 2010
- Circulating brain-reactive autoantibodies and behavioral deficits in the MRL model of CNS lupus. Journal of Neuroimmunology. 218:73-82. 2010
- A novel experimental approach in treating central nervous system lupus: Kudos and Kicks. Arthritis and Rheumatism. 60:3531-3533. 2009
- Disturbed distribution of proliferative brain cells during lupus-like disease. Brain, Behavior, and Immunity. 23:1003-1013. 2009
- Neuropsychiatric lupus and association with cerebrospinal fluid immunoglobulins: a pilot study.. Israel Medical Association Journal. 11:359-362. 2009
- Time course and nature of brain atrophy in the MRL mouse model of central nervous system lupus. Arthritis and Rheumatism. 60:1764-1774. 2009
- Proclivity to self-injurious behavior in MRL-lpr mice: implications for autoimmunity-induced damage in the dopaminergic system. Molecular Psychiatry. 13:1043-1053. 2008
- Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: Evidence of autoimmune-induced pain?. Brain, Behavior, and Immunity. 22:1208-1216. 2008
- Ibuprofen fails to prevent brain pathology in a model of neuropsychiatric lupus.. Journal of Rheumatology. 33:2199-2213. 2006
- Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mice. Journal of Neuroimmunology. 179:26-36. 2006
- Evaluation of the autoreactivity of the Cuban Heberbiovac-HB and Vax-TET vaccines in Balb/c mice. Revista Cubana de Investigaciones Biomedicas. 25. 2006
- Chronic anti-inflammatory treatment fails to prevent CNS disease in lupus-prone mice. Annals of General Psychiatry. 5:s212. 2006
- Impaired response to amphetamine and neuronal degeneration in the nucleus accumbens of autoimmune MRL-lpr mice. Behavioural Brain Research. 166:32-38. 2006
- Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease. Journal of Neuroimmunology. 169:68-85. 2005
- Elevated immunoglobulin levels in the cerebrospinal fluid from lupus-prone mice. Journal of Neuroimmunology. 165:104-113. 2005
- Behavioral heterogeneity in an animal model of neuropsychiatric lupus. Biological Psychiatry. 57:679-687. 2005
- Erratum to “Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice” [J. Neuroimmunol. 152 (2004) 83–97]. Journal of Neuroimmunology. 156:211-211. 2004
- Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. Journal of Neuroimmunology. 152:83-97. 2004
- Behavioral effects of infection with interferon-gamma adenovector. Behavioural Brain Research. 151:73-82. 2004
- Hippocampal damage in mouse and human forms of systemic autoimmune disease. Hippocampus. 14:649-661. 2004
- Taste responsiveness and diet preference in autoimmune MRL mice. Behavioural Brain Research. 140:119-130. 2003
- Neural stem cell cytotoxic activity in cerebrospinal fluid from a patient with end-stage neuropsychiatric systemic lupus erythematosus. Journal of Allergy and Clinical Immunology. 111:S318-S318. 2003
- Neurodegeneration in autoimmune MRL-lpr mice as revealed by Fluoro Jade B staining. Brain Research. 964:200-210. 2003
- Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidence. Journal of Neuroimmunology. 129:84-96. 2002
- Neurotoxic properties of cerebrospinal fluid from behaviorally impaired autoimmune mice. Brain Research. 920:183-193. 2001
- Behavioral Effects of Infection with IL-6 Adenovector. Brain, Behavior, and Immunity. 15:25-42. 2001
- Immunosuppression prevents neuronal atrophy in lupus-prone mice:. Journal of Neuroimmunology. 111:93-101. 2000
- Increased TUNEL staining in brains of autoimmune Fas-deficient mice. Journal of Neuroimmunology. 104:147-154. 2000
- Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction. Journal of Neuroimmunology. 96:80-91. 1999
- POSSIBLE IMMUNE ACTIVATION OF DEPRESSION REVEALED BY LUPUS-PRONE MRL MICE. Behavioural Pharmacology. 9:S84-S84. 1998
- POSSIBLE IMMUNE ACTIVATION OF DEPRESSION REVEALED BY LUPUS-PRONE MRL MICE. Behavioural Pharmacology. 9:S84-S84. 1998
- POSSIBLE IMMUNE ACTIVATION OF DEPRESSION REVEALED BY LUPUS-PRONE MRL MICE. Behavioural Pharmacology. 9:S84-S84. 1998
- Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice. Journal of Neuroimmunology. 87:162-170. 1998
- Reduced Aggressiveness and Low Testosterone Levels in Autoimmune MRL-lpr Males. Physiology and Behavior. 63:305-309. 1998
- Animal Models for Nervous System Disease in Systemic Lupus Erythematosus. Annals of the New York Academy of Sciences. 823:97-106. 1997
- Effect of cyclophosphamide on leukocytic infiltration in the brain of MRL/lpr mice. Lupus. 6:268-274. 1997
- Review: Behaviour of MRL Mice: An Animal Model of Disturbed Behaviour in Systemic Autoimmune Disease. Lupus. 6:223-229. 1997
- Neurobehavioral alterations in autoimmune mice. Neuroscience and Biobehavioral Reviews. 21:327-340. 1997
- Reduced Preference for Sucrose in Autoimmune Mice. Brain Research Bulletin. 44:155-165. 1997
- Joint pathology and behavioral performance in autoimmune MRL-lpr mice. Physiology and Behavior. 60:901-905. 1996
- Joint Pathology and Behavioral Performance in Autoimmune MRL-lpr Mice. Physiology and Behavior. 60:901-905. 1996
- Blunted Sensitivity to Sucrose in Autoimmune MRL-lpr Mice: A Curve-Shift Study. Brain Research Bulletin. 41:305-311. 1996
- Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr mice. Physiology and Behavior. 58:797-802. 1995
- VISUALIZATION OF NUCLEOLAR ORGANIZER REGIONS IN SLOTHS (BRADYPUS-VARIEGATUS AND SCAEOPUS-TORQUATUS). Genetics and Molecular Biology. 18:111-113. 1995
- Nervous System Lupus: Pathogenesis and Rationale for Therapy. Scandinavian Journal of Rheumatology. 24:263-273. 1995
- Disturbed emotionality in autoimmune MRL-lpr mice. Physiology and Behavior. 56:609-617. 1994
- Behavior and Immune Status of MRL Mice in the Postweaning Period. Brain, Behavior, and Immunity. 8:1-13. 1994
- Brain-reactive antibodies and behavior of autoimmune MRL-lpr mice. Physiology and Behavior. 54:1025-1029. 1993
- Spatial learning during the course of autoimmune disease in MRL mice. Behavioural Brain Research. 54:57-66. 1993
- A behavioral profile of autoimmune lupus-prone MRL mice. Brain, Behavior, and Immunity. 6:265-285. 1992
- Self-stimulation behavior: Consequences upon immunity?. Brain, Behavior, and Immunity. 4:255-264. 1990
- ELECTRO-ACUPUNCTURE MODIFIES HUMORAL IMMUNE RESPONSE IN THE RAT. Acupuncture and Electro-Therapeutics Research. 14:115-120. 1989
- Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST). Journal of Visualized Experiments.
- Poster Presentations at the 9th Canadian Conference on Dementia (CCD) Toronto, November 2017. Canadian Geriatrics Journal. 21:71-133.
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preprints