Regional Metabolic Assessment of Human Brain during Development by Proton Magnetic Resonance Spectroscopy In Vivo and by High-Performance Liquid Chromatography/Gas Chromatography in Autopsy Tissue

To study the course of regional metabolite concentrations during early brain development, we measured in vivo metabolites [N-acetyl-aspartate (NAA), choline-containing compounds, and myo-inositol (M-Ino)] in the precentral area of the cerebrum by short echo-time single volume proton magnetic resonance spectroscopy and compared in vivo established spectroscopic data with classic chromatographic data (HPLC) on age-corresponding autopsy tissue in …