Journal article
Organic Anion Transporting Polypeptide 2B1 and Breast Cancer Resistance Protein Interact in the Transepithelial Transport of Steroid Sulfates in Human Placenta
Abstract
The human placenta has both protective and nurturing functions for the fetal organism. Uptake and elimination of xenobiotics and endogenous substances are facilitated by various transport proteins from the solute carrier (SLC) and ABC families, respectively. A functional interaction of uptake and elimination, which is a prerequisite for vectorial transport across cellular barriers, has not been described for placenta. In this study, we examined …
Authors
Grube M; Reuther S; Schwabedissen HMZ; Köck K; Draber K; Ritter CA; Fusch C; Jedlitschky G; Kroemer HK
Journal
Drug Metabolism and Disposition, Vol. 35, No. 1, pp. 30–35
Publisher
Elsevier
Publication Date
January 2007
DOI
10.1124/dmd.106.011411
ISSN
0090-9556
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily G, Member 2ATP-Binding Cassette TransportersAnimalsBiological TransportCell LineCell MembraneDehydroepiandrosterone SulfateDogsEstradiolEstroneFemaleHumansNeoplasm ProteinsOrganic Anion TransportersOrganic Anion Transporters, Sodium-IndependentPlacentaRNA, Messenger