Journal article
Role of the Multidrug Transporter Proteins ABCB1 and ABCC2 in the Diaplacental Transport of Talinolol in the Term Human Placenta
Abstract
Placental syncytiotrophoblasts are known to express the efflux transporter proteins P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2), which are supposed to be a functional part of the human placental barrier. With advancing gestational age, expression of ABCB1 decreases progressively, whereas ABCC2 is more expressed. To evaluate to which extent they contribute to placental barrier function at term, permeability of …
Authors
May K; Minarikova V; Linnemann K; Zygmunt M; Kroemer HK; Fusch C; Siegmund W
Journal
Drug Metabolism and Disposition, Vol. 36, No. 4, pp. 740–744
Publisher
Elsevier
Publication Date
April 2008
DOI
10.1124/dmd.107.019448
ISSN
0090-9556
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Biological TransportCross-Over StudiesFemaleHumansMaternal-Fetal ExchangeMembrane Transport ProteinsMultidrug Resistance-Associated Protein 2Multidrug Resistance-Associated ProteinsPlacentaPregnancyPropanolamines