Journal article
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response[S]
Abstract
Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress. Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown that markers of ER stress/UPR activation, including GRP78, phospho-eIF2, and spliced XBP1, are upregulated during adipogenesis. Given these findings, the objective of this study was to …
Authors
Basseri S; Lhoták Š; Sharma AM; Austin RC
Journal
Journal of Lipid Research, Vol. 50, No. 12, pp. 2486–2501
Publisher
Elsevier
Publication Date
December 2009
DOI
10.1194/jlr.m900216-jlr200
ISSN
0022-2275
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3T3-L1 CellsAdipocytesAdipogenesisAnimalsBody WeightCells, CulturedDNA-Binding ProteinsDietary SupplementsEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPFemaleMiceMice, Inbred C57BLPhenylbutyratesProtein FoldingRegulatory Factor X Transcription FactorsTranscription FactorsX-Box Binding Protein 1