Expanding indications for the use of thrombolytic agents in acute myocardial infarction

A large body of data from randomized clinical trials have definitely established that thrombolytic therapy in acute myocardial infarction reduces the risk of early mortality by approximately one fourth. Unfortunately, most (but not all) trials have been unduly restrictive in selecting patients who have been entered. Consequently, at least half of the patients (many of whom are at high risk of death) who present with signs and symptoms of acute …