Journal article
Randomized trial of candesartan cilexetil in the treatment of patients with congestive heart failure and a history of intolerance to angiotensin-converting enzyme inhibitors
Abstract
BACKGROUND: Many patients with congestive heart failure do not receive the benefits of angiotensin-converting enzyme (ACE) inhibitors because of intolerance. We sought to determine the tolerability of an angiotensin II receptor blocker, candesartan cilexetil, among patients considered intolerant of ACE inhibitors.
METHODS: Patients with CHF, left ventricular ejection fraction less than 35%, and history of discontinuing an ACE inhibitor because …
Authors
Granger CB; Ertl G; Kuch J; Maggioni AP; McMurray J; Rouleau J-L; Stevenson LW; Swedberg K; Young J; Yusuf S
Journal
American Heart Journal, Vol. 139, No. 4, pp. 609–617
Publisher
Elsevier
Publication Date
April 2000
DOI
10.1016/s0002-8703(00)90037-1
ISSN
0002-8703
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBenzimidazolesBiphenyl CompoundsCause of DeathDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleHeart FailureHemodynamicsHumansMaleMiddle AgedPilot ProjectsSurvival RateTetrazolesVentricular Dysfunction, LeftVentricular Function, Left